INFLAMMATORY BOWEL DISEASE · CONDITION GUIDE
Ulcerative Colitis
A chronic inflammatory condition of the colon and rectum causing bloody diarrhoea, urgency, and systemic illness — surgical treatment offers definitive cure in selected patients.
ABOUT THIS CONDITION
What is Ulcerative Colitis?
Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the mucosal lining of the colon and rectum. Unlike Crohn’s disease, UC is limited to the large bowel and follows a continuous pattern from the rectum proximally. It presents with bloody diarrhoea, urgency, abdominal cramps, and in severe cases, systemic sepsis or toxic megacolon. Long-standing extensive UC carries an increased risk of colorectal cancer. Dr. Tagore Mohan Grandhi performs surgery for ulcerative colitis at Lux Hospitals, Hyderabad. Unlike Crohn’s disease, colectomy is curative for UC. Surgery is indicated for acute severe UC not responding to medical therapy, chronic debilitating disease, dysplasia, or colorectal cancer. Proctocolectomy with ileal pouch-anal anastomosis (IPAA / J-pouch) restores bowel continuity and avoids a permanent stoma.
SIGNS TO WATCH
Common Symptoms
Symptoms that need attention
WHY IT HAPPENS
Causes & Risk Factors
- Abnormal immune response to colonic bacteria in genetically predisposed individuals
- Genetic susceptibility — family history increases risk significantly
- Dysbiosis of the gut microbiome triggering mucosal inflammation
- Environmental factors including hygiene, diet, and urban lifestyle
- Impaired mucosal barrier function and altered immune regulation
- Prior gastrointestinal infection as a potential trigger in susceptible individuals
CLINICAL DETAILS
KeyFacts
Total colectomy is curative for ulcerative colitis
IPAA / J-pouch avoids permanent stoma
Colonoscopic surveillance essential in long-standing UC
Full pouch function achieved over 3–6 months
4–8 stools per day on average after J-pouch
Available at Lux Hospitals, Hitech City, Hyderabad
HOW WE TREAT IT
Treatment Approach
Ileal Pouch-Anal Anastomosis (IPAA / J-Pouch)
The ileal pouch-anal anastomosis is the preferred restorative procedure for ulcerative colitis, creating an internal reservoir from the small bowel and connecting it to the anus. This avoids a permanent stoma while curing the disease. Dr. Grandhi performs IPAA as a laparoscopic procedure with excellent long-term functional results.
- 1
Assessment & MDT Planning
Colonoscopy, biopsies, and cross-sectional imaging assess disease extent, exclude dysplasia, and confirm surgical indication. Stoma nurse assessment and psychological preparation are undertaken.
- 2
Surgical Planning
The procedure is planned as a two- or three-stage operation. Stage one removes the colon and creates the pouch with a temporary ileostomy. Stage two closes the ileostomy once pouch healing is confirmed.
- 3
Proctocolectomy and Pouch Formation
The entire colon and rectum are removed laparoscopically. A J-shaped ileal reservoir is fashioned and connected to the anal canal. A temporary loop ileostomy protects the new anastomosis during healing.
- 4
Ileostomy Reversal & Rehabilitation
The temporary ileostomy is reversed at 8–12 weeks following confirmation of a satisfactory pouch on contrast study. Pelvic floor physiotherapy and dietary support optimise functional outcomes.
AVAILABLE TREATMENTS
TreatmentOptions
Ileoanal Reservoir Surgery (IPAA / J-Pouch)
Total proctocolectomy with construction of an ileal pouch-anal anastomosis — the preferred restorative operation for UC that avoids a permanent stoma and restores bowel continuity.
Primary Bowel Resection
Emergency or urgent subtotal colectomy with end ileostomy for acute severe UC not responding to intensive medical therapy.
Ileostomy
Permanent end ileostomy following proctocolectomy in patients unsuitable for or declining pouch surgery, or where sphincter function is compromised.
COMMON QUESTIONS
Frequently Asked Questions
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